Police were called at 4.31pm on Sunday, August 22 following reports of a stabbing in a house on Lea Bridge Road.
Officers rushed to the scene along with London Ambulance Service paramedics and the London Air Ambulance and found a 32-year-old man with life-threatening injuries.
An investigation is underway but there have been no arrests at this stage.
Gerry Campbell MBE, a former detective chief superintendent at Scotland Yard, tweeted: “Terrible news again as another person is stabbed to death in #London #WalthamForest. This afternoon a 32 year old man was stabbed in #Leyton and died at hospital.
“Truly tragic news awaits loved ones and friends.”
Anyone with information about the incident, is asked to call 101, giving the reference 4806/22AUG.
Information can also be provided to Crimestoppers, anonymously, on 0800 555 111.