The teenager was knifed outside a charity shop just yards from a police station in Barkingside.
Emergency services raced to the scene after the attack near to the junction with Horace Road.
The boy was found lying in the street with stab wounds before he was rushed to hospital by paramedics.
Pictures from the scene after the attack shows several uniformed officers standing guard at a police cordon.
London’s Air Ambulance was also scrambled.
A Met Police spokesman said: “Next of kin have been informed. A crime scene is in place.
“No arrests have been made and enquiries continue.”
A London Ambulance Service spokesman said: “We sent an ambulance crew, a single responder in a car and an incident response officer to the scene. We also dispatched London’s Air Ambulance to the scene.
“We treated a man at the scene and took him as a priority to a hospital in east London.”