First pill to treat Covid gets approval in UK

The new treatment targets an enzyme that the virus uses to make copies of itself, introducing errors into its genetic code. That should prevent it from multiplying, so keeping virus levels low in the body and reducing the severity of the disease.

Merck said that approach should make the treatment equally effective against new variants of the virus as it evolves in the future.

The UK regulator, the MHRA, said the tablet had been authorised for use in people who have mild to moderate Covid and at least one risk factor for developing severe illness such as obesity, old age, diabetes or heart disease.

The organisation’s chief executive, June Raine, described it as “another therapeutic to add to our armoury against Covid-19”.

“It is the world’s first approved antiviral for this disease that can be taken by mouth rather than administered intravenously,” she said.

“This is important, because it means it can be administered outside of a hospital setting, before Covid-19 has progressed to a severe stage.”

England’s deputy chief medical officer, Prof Jonathan Van-Tam, warned on Wednesday of some “hard months to come” in the pandemic.

He said that while Covid cases appeared to have stabilised, deaths were rising and there were signs infections were starting to “penetrate” older age groups.

The UK recorded 41,229 Covid cases on Wednesday and 217 deaths within 28 days of a positive test.